Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNRMTX)

Drug Name

13,14-dihydro-16-m-chlorophenoxy-w-tetranor-PGF1alpha Drug Info

Synonyms

CHEMBL36041; 7-[(1R,2R,3R,5S)-2-[(3R)-4-(3-chlorophenoxy)-3-hydroxybutyl]-3,5-dihydroxycyclopentyl]heptanoic acid; AC1NSKAB; GTPL1955; 13,14-dihydro-16-m-chlorophenoxy-w-tetranor-PGF1alpha; 13,14-Dihydro-16-m-Chlorophenoxy-Omega-Tetranor PGF-1alpha; BDBM50085911; 7-{2-[4-(3-Chloro-phenoxy)-3-hydroxy-butyl]-3,5-dihydroxy-cyclopentyl}-heptanoic acid; 7-[(1R)-2beta-[(3R)-3-Hydroxy-4-(3-chlorophenoxy)butyl]-3alpha,5alpha-dihydroxycyclopentane-1alpha-yl]heptanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5311240
TTD Drug ID: DMNRMTX

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin F2-alpha receptor (PTGFR)	TTT2ZAR	PF2R_HUMAN	Agonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Prostaglandin F2-alpha receptor (PTGFR)	DTT	PTGFR	0.379	2.744	3.609	1.138

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin F2-alpha receptor (PTGFR)	DTT	PTGFR	8.25E-02	-0.05	-0.14

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1955).
2	Design and synthesis of 13,14-dihydro prostaglandin F(1alpha) analogues as potent and selective ligands for the human FP receptor. J Med Chem. 2000 Mar 9;43(5):945-52.