General Information of Drug (ID: DMNRUGA)

Drug Name
FR-121196 Drug Info
Synonyms
FR-121196; FR 121196; 133920-65-7; N-(4-Acetyl-1-piperazinyl)-4-fluorobenzenesulfonamide; PZQKOVUNWPDCCQ-UHFFFAOYSA-N; FR121196; ACMC-20mv5f; AC1L2ZLZ; SCHEMBL195526; CTK4B8875; DTXSID90158423; Piperazine, 1-acetyl-4-(((4-fluorophenyl)sulfonyl)amino)-
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Terminated [1]
Cross-matching ID
PubChem CID
131688
CAS Number
CAS 133920-65-7
TTD Drug ID
DMNRUGA

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Somatostatin receptor type 1 (SSTR1) TTIND6G SSR1_HUMAN Modulator [2]
Somatostatin receptor type 2 (SSTR2) TTZ6T9E SSR2_HUMAN Modulator [3]
Somatostatin receptor type 3 (SSTR3) TTJX3UE SSR3_HUMAN Modulator [2]
Somatostatin receptor type 4 (SSTR4) TTAE1BR SSR4_HUMAN Modulator [3]
Somatostatin receptor type 5 (SSTR5) TT2BC4G SSR5_HUMAN Modulator [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Somatostatin receptor type 2 (SSTR2) DTT SSTR2 4.703 4.931 5.624 5.184
Somatostatin receptor type 3 (SSTR3) DTT SSTR3 3.087 2.07 3.263 2.036
Somatostatin receptor type 1 (SSTR1) DTT SSTR1 5.588 3.392 4.087 4.009
Somatostatin receptor type 4 (SSTR4) DTT SSTR4 5.615 5.998 3.7 6.158
Somatostatin receptor type 5 (SSTR5) DTT SSTR5 2.104 0.585 0.585 2.585
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Alzheimer disease
ICD Disease Classification 8A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Somatostatin receptor type 2 (SSTR2) DTT SSTR2 9.79E-07 -0.38 -0.65
Somatostatin receptor type 3 (SSTR3) DTT SSTR3 2.40E-04 -0.09 -0.56
Somatostatin receptor type 1 (SSTR1) DTT SSTR1 2.39E-14 -0.6 -0.83
Somatostatin receptor type 4 (SSTR4) DTT SSTR4 1.12E-02 -0.07 -0.32
Somatostatin receptor type 5 (SSTR5) DTT SSTR5 2.74E-01 -0.04 -0.26
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001380)
2 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
3 Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196, a putative cognitive enhancer. Eur J Pharmacol. 1993 Sep 7;241(1):27-34.