Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNRUGA)

Drug Name

FR-121196 Drug Info

Synonyms

FR-121196; FR 121196; 133920-65-7; N-(4-Acetyl-1-piperazinyl)-4-fluorobenzenesulfonamide; PZQKOVUNWPDCCQ-UHFFFAOYSA-N; FR121196; ACMC-20mv5f; AC1L2ZLZ; SCHEMBL195526; CTK4B8875; DTXSID90158423; Piperazine, 1-acetyl-4-(((4-fluorophenyl)sulfonyl)amino)-

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Terminated	[1]

Cross-matching ID

PubChem CID: 131688
CAS Number: CAS 133920-65-7
TTD Drug ID: DMNRUGA

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Somatostatin receptor type 1 (SSTR1)	TTIND6G	SSR1_HUMAN	Modulator	[2]
Somatostatin receptor type 2 (SSTR2)	TTZ6T9E	SSR2_HUMAN	Modulator	[3]
Somatostatin receptor type 3 (SSTR3)	TTJX3UE	SSR3_HUMAN	Modulator	[2]
Somatostatin receptor type 4 (SSTR4)	TTAE1BR	SSR4_HUMAN	Modulator	[3]
Somatostatin receptor type 5 (SSTR5)	TT2BC4G	SSR5_HUMAN	Modulator	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Somatostatin receptor type 2 (SSTR2)	DTT	SSTR2	4.703	4.931	5.624	5.184
Somatostatin receptor type 3 (SSTR3)	DTT	SSTR3	3.087	2.07	3.263	2.036
Somatostatin receptor type 1 (SSTR1)	DTT	SSTR1	5.588	3.392	4.087	4.009
Somatostatin receptor type 4 (SSTR4)	DTT	SSTR4	5.615	5.998	3.7	6.158
Somatostatin receptor type 5 (SSTR5)	DTT	SSTR5	2.104	0.585	0.585	2.585

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Alzheimer disease

ICD Disease Classification

8A20

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Somatostatin receptor type 2 (SSTR2)	DTT	SSTR2	9.79E-07	-0.38	-0.65
Somatostatin receptor type 3 (SSTR3)	DTT	SSTR3	2.40E-04	-0.09	-0.56
Somatostatin receptor type 1 (SSTR1)	DTT	SSTR1	2.39E-14	-0.6	-0.83
Somatostatin receptor type 4 (SSTR4)	DTT	SSTR4	1.12E-02	-0.07	-0.32
Somatostatin receptor type 5 (SSTR5)	DTT	SSTR5	2.74E-01	-0.04	-0.26

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001380)
2	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
3	Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196, a putative cognitive enhancer. Eur J Pharmacol. 1993 Sep 7;241(1):27-34.