Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNST69)

Drug Name
Metaiodobenzylguanidine I-131 Drug Info
Synonyms Azedra (TN)
Indication
Disease Entry ICD 11 Status REF
Neuroblastoma 2D11.2 Phase 2 [1]
Neuroendocrine cancer 2B72.1 Phase 2 [2]
Pheochromocytoma 5A75 Application submitted [3]
Cross-matching ID
PubChem CID
71184
ChEBI ID
CHEBI:135997
CAS Number
CAS 77679-27-7
TTD Drug ID
DMNST69

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Norepinephrine transporter (NET) TTAWNKZ SC6A2_HUMAN Modulator [4]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Norepinephrine transporter (NET) DTT SLC6A2 2.459 3.426 3.322 3.35
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Neuroblastoma
ICD Disease Classification 2D11.2
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Norepinephrine transporter (NET) DTT SLC6A2 7.05E-01 7.02E-03 0.07
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004852)
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Imaging the norepinephrine transporter in neuroblastoma: a comparison of [18F]-MFBG and 123I-MIBG. Clin Cancer Res. 2014 Apr 15;20(8):2182-91.