Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNU2RM)

Drug Name

4-(piperazin-1-yl)thieno[2,3-d]pyrimidine Drug Info

Synonyms

4-(piperazin-1-yl)thieno[2,3-d]pyrimidine; 373356-48-0; 1-{thieno[2,3-d]pyrimidin-4-yl}piperazine; 4-piperazin-1-ylthieno[2,3-d]pyrimidine; CHEMBL596108; 1-(Thieno[2,3-d]pyrimidin-4-yl)piperazine; AC1Q1I4T; SCHEMBL4922800; CTK7D1707; MolPort-001-760-894; ZINC12954996; SBB095996; BDBM50304810; AKOS000123564; MCULE-6714459164; PS-3311; NE24045; KS-000029X0; 4-piperazinylthiopheno[2,3-d]pyrimidine; KB-85055; DA-06355; 4-Piperazin-1-yl-thieno[2,3-d]pyrimidine; KB-243074; FT-0727983; EN300-29445; Thieno[2,3-d]pyrimidine, 4-(1-piperaziny

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 16768198
CAS Number: CAS 373356-48-0
TTD Drug ID: DMNU2RM

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2C receptor (HTR2C)	TTWJBZ5	5HT2C_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2C receptor (HTR2C)	DTT	HTR2C	4.233	3.329	3.843	3.888

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2C receptor (HTR2C)	DTT	HTR2C	1.02E-02	-0.45	-0.37
5-HT 2C receptor (HTR2C)	DTT	HTR2C	2.27E-01	0.27	0.6

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71.