Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNV8SY)

Drug Name
SNN-0029 Drug Info
Synonyms VEGF (intracerebroventricular, amyotrophic lateral sclerosis), NeuroNova/VIB/Genentech
Indication
Disease Entry ICD 11 Status REF
Lateral sclerosis 8B61 Phase 1/2 [1]
Cross-matching ID
TTD Drug ID
DMNV8SY

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Vascular endothelial growth factor A (VEGFA) TTOHSBA VEGFA_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Vascular endothelial growth factor A (VEGFA) DTT VEGFA 8.544 6.927 7.253 7.839
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 08 Disease of the nervous system
Disease Class ICD-11: 8A00 Parkinsonism
The Studied Tissue Cervical spinal cord
The Studied Disease Lateral sclerosis [ICD-11:8A00.0]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Vascular endothelial growth factor A (VEGFA) DTT VEGFA 3.61E-01 0.15 0.47
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01384162) An Open Label, Safety and Tolerability Continuation Study of Intracerebroventricular Administration of sNN0029 to Patients With Amyotrophic Lateral Sclerosis. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of Neuronova.