General Information of Drug (ID: DMO3486)

Drug Name
COSALANE Drug Info
Synonyms
Cosalane; AC1L2I0J; CHEMBL300101; CTK6A7531; BDBM50036146; LS-187298; 5-[1-(3-carboxy-5-chloro-4-hydroxyphenyl)-4-[(3S,10S,13R,17R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]but-1-enyl]-3-chloro-2-hydroxybenzoic acid; 5-{1-(3-carboxy-5-chloro-4-hydroxyphenyl-4-[1-(1,5-dimethylhexyl)-9a,11a-dimethylperhydrocyclopenta[a]phenanthren-7-yl]-1-butenyl}-3-chloro-2-hydroxy acetic acid (Cosalane)
Cross-matching ID
PubChem CID
455040
CAS Number
CAS 154212-56-3
TTD Drug ID
DMO3486

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
C-C chemokine receptor type 1 (CCR1) TTC24WT CCR1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
C-C chemokine receptor type 1 (CCR1) DTT CCR1 6.209 5.498 5.781 6.138
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
C-C chemokine receptor type 1 (CCR1) DTT CCR1 3.93E-01 0.11 0.22
C-C chemokine receptor type 1 (CCR1) DTT CCR1 2.85E-04 0.54 0.68
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds. Bioorg Med Chem Lett. 2001 Jan 8;11(1):59-62.