Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMO91EH)

Drug Name

4,5,6,7-tetrahydroisoxazolo-[5,4-c]-pyridin-3-ol Drug Info

Synonyms

THIP hydrochloride; GABOXADOL HYDROCHLORIDE; 85118-33-8; UNII-478RVH3TVD; 478RVH3TVD; 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride; 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL HCL, GABOXADOL-HCL; SR-01000075651; EINECS 285-687-7; THIP NIEaNI; THIP HCl; AC1NWAX4; Gaboxadol (hydrochloride); MLS002154080; SPECTRUM1503648; CHEMBL1255746; CTK8G3449; DTXSID90234251; AOB5024; MolPort-006-141-665; MolPort-003-666-496; HMS1571C05; Pharmakon1600-01503648; BCP16610; Tox21_501233; BN0520; NSC759585; CCG-39368

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5702253
CAS Number: CAS 85118-33-8
TTD Drug ID: DMO91EH

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA (GRIA)	TTAN6JD	NOUNIPROTAC	Agonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glutamate receptor AMPA (GRIA)	DTT	GRIA	3.07	2.907	2.945	3.485

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate receptor AMPA (GRIA)	DTT	NO-GeName	1.79E-04	-0.69	-0.58

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Reduction in potency of selective gamma-aminobutyric acidA agonists and diazepam in CA1 region of in vitro hippocampal slices from chronic flurazepam-treated rats. J Pharmacol Exp Ther. 1992 Jul;262(1):204-11.