Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOC67J)

Drug Name

1-(4-Nitro-phenyl)-2-phenyl-ethane-1,2-dione Drug Info

Synonyms

4-Nitrobenzil; 1-(4-nitrophenyl)-2-phenylethane-1,2-dione; 22711-24-6; Benzil, 4-nitro-; p-Nitrobenzil; Ethanedione, (4-nitrophenyl)phenyl-; NSC139153; Benzil-based compound, 27; AC1Q5B1C; AC1L5ZN0; SCHEMBL1370034; CHEMBL192589; BDBM22749; CTK4F0012; 4-Nitrobibenzyl-alpha,beta-dione; DTXSID10300826; GPDKREBNFFEDHW-UHFFFAOYSA-N; MolPort-000-146-024; ZX-AT021384; ZINC2555760; STK325617; SBB101571; AKOS004902243; OR28786; NSC-139153; MCULE-2855880102; ACM22711246; KB-147450; DB-045974; FT-0605764; ST51043016

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 283893
CAS Number: CAS 22711-24-6
TTD Drug ID: DMOC67J

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Liver carboxylesterase (CES1)	TTMF541	EST1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Liver carboxylesterase (CES1)	DTT	CES1	12.04	6.525	5.311	5.909

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Liver carboxylesterase (CES1)	DTT	CES1	3.82E-08	1.86	1.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15.