General Information of Drug (ID: DMOEIHC)

Drug Name
[1,3]Thiazinan-(2E)-ylideneamine Drug Info
Synonyms
2-Amino-5,6-dihydro-4H-1,3-thiazine; 5,6-Dihydro-4H-1,3-thiazin-2-amine; 30480-64-9; CHEMBL306541; 2-Iminotetrahydro-1,3-thiazine; [1,3]Thiazinan-(2E)-ylideneamine; AC1Q4UKS; AC1L4O0Q; SCHEMBL30950; 2799-75-9 (hydrobromide); CTK4G5273; DTXSID60184552; [1,3]Thiazinan-(2Z)-ylideneamine; BDBM50049250; ZINC17744492; FCH991782; AKOS006347653; AKOS003362396; 4H-1,3-Thiazin-2-amine,5,6-dihydro-; EN300-203949; 3,4,5,6-Tetrahydro-2H-1,3-thiazin-2-imine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
189081
CAS Number
CAS 30480-64-9
TTD Drug ID
DMOEIHC

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nitric-oxide synthase brain (NOS1) TTZUFI5 NOS1_HUMAN Inhibitor [1]
Nitric-oxide synthase endothelial (NOS3) TTCM4B3 NOS3_HUMAN Inhibitor [1]
Nitric-oxide synthase inducible (NOS2) TTF10I9 NOS2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Nitric-oxide synthase brain (NOS1) DTT NOS1 6.085 5.844 5.849 5.806
Nitric-oxide synthase inducible (NOS2) DTT NOS2 4.95 5.198 4.573 5.121
Nitric-oxide synthase endothelial (NOS3) DTT NOS3 4.787 4.154 5.133 3.053
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Nitric-oxide synthase inducible (NOS2) DTT NOS2 4.24E-02 -0.27 -0.88
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72.