Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOGNXY)

Drug Name
Sarilumab Drug Info
Synonyms Kevzara
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [2]
Cross-matching ID
TTD Drug ID
DMOGNXY

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin 6 receptor (IL6R) TT0E5SK IL6RA_HUMAN; IL6RB_HUMAN Modulator [3]
HUMAN interleukin-6 receptor (IL6R) TTDVAKP IL6RA_HUMAN; IL6RB_HUMAN Blocker [4]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Interleukin 6 receptor (IL6R) DTT IL6R 6.42 5.564 5.031 5.404
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Rheumatoid arthritis
ICD Disease Classification FA20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Interleukin 6 receptor (IL6R) DTT IL6R; IL6ST 5.77E-01 -0.24 -0.47
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 ClinicalTrials.gov (NCT04327388) Sarilumab COVID-19
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 IL-6 as a keystone cytokine in health and disease. Nat Immunol. 2015 May;16(5):448-57.