Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOGV9F)

• Drug Name: NSC-2113 Drug Info
• Synonyms: 1,4-Diethoxybenzene; 122-95-2; Benzene, 1,4-diethoxy-; p-Diethoxybenzene; Hydroquinone diethyl ether; Benzene, p-diethoxy-; NSC-2113; 1,4-diethoxy-benzen; UNII-C6Y51501JB; CHEMBL219898; VWGNFIQXBYRDCH-UHFFFAOYSA-N; C6Y51501JB; Benzene,4-diethoxy-; NSC2113; NSC 2113; EINECS 204-585-5; 1,4-diethoxybenzol; hydroquinonedlethylether; ACMC-209ans; AI3-09458; AC1Q37UB; AC1L26YB; KSC174M8J; SCHEMBL124015; Benzene, p-diethoxy- (8CI); Jsp001542; DTXSID9059549; CTK0H4684; KS-00000WIN; MolPort-001-759-994; ZINC394919; NSC68808; SBB060362

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 67150
  CAS Number: CAS 122-95-2
  TTD Drug ID: DMOGV9F

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Quinone reductase 1 (NQO1)	TT8XK6L	NQO1_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Quinone reductase 1 (NQO1)	DTT	NQO1	5.453	7.493	8.082	7.086

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Quinone reductase 1 (NQO1)	DTT	NQO1	2.05E-04	0.89	2.67

References

• [1] In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54.