Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOPUIH)

Drug Name

PMID15546730C2 Drug Info

Synonyms

UNII-N9PH4O199D; N9PH4O199D; GTPL8136; BDBM13268

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1] , [2]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
B lymphocyte kinase (BLK)	TTNDSC3	BLK_HUMAN	Inhibitor	[2]
Fyn tyrosine protein kinase (FYN)	TT2B9KF	FYN_HUMAN	Inhibitor	[2]
Hematopoietic cell kinase (HCK)	TT42OGM	HCK_HUMAN	Inhibitor	[2]
Janus kinase 3 (JAK-3)	TTT7PJU	JAK3_HUMAN	Inhibitor	[2]
LCK tyrosine protein kinase (LCK)	TT860QF	LCK_HUMAN	Inhibitor	[2]
Proto-oncogene c-Src (SRC)	TT6PKBN	SRC_HUMAN	Inhibitor	[2]
Tyrosine-protein kinase Fgr (FGR)	TTPOGS1	FGR_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Janus kinase 3 (JAK-3)	DTT	JAK3	2.104	3.248	2.848	4.485
LCK tyrosine protein kinase (LCK)	DTT	LCK	5.2	4.443	4.53	6.325
Proto-oncogene c-Src (SRC)	DTT	SRC	2.907	3.35	3.498	4.75
Fyn tyrosine protein kinase (FYN)	DTT	FYN	5.805	4.747	5.545	6.468

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Janus kinase 3 (JAK-3)	DTT	JAK3	4.94E-03	0.28	1.41
LCK tyrosine protein kinase (LCK)	DTT	LCK	4.46E-02	-0.13	-1.09
Proto-oncogene c-Src (SRC)	DTT	SRC	7.46E-03	-0.2	-1.24
Fyn tyrosine protein kinase (FYN)	DTT	FYN	2.29E-01	-0.1	-0.51

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck). Bioorg Med Chem Lett. 2003 Nov 17;13(22):4007-10.
2	Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6.