Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOX8JF)

Drug Name

ISIS 107652 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Caspase 8 messenger RNA (CASP8 mRNA)	TT6SZNG	CASP8_HUMAN	Not Available	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Caspase 8 messenger RNA (CASP8 mRNA)	DTT	CASP8	5.477	5.033	5.668	5.261

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Caspase 8 messenger RNA (CASP8 mRNA)	DTT	CASP8	8.78E-06	1.43	4.51

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	US patent application no. 6,258,600, Antisense modulation of caspase 8 expression.