Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOXDIY)

Drug Name
CB-5339 Drug Info
Indication
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Phase 1 [1]
Myelodysplastic syndrome 2A37 Phase 1 [1]
Cross-matching ID
PubChem CID
122685543
TTD Drug ID
DMOXDIY

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Valosin-containing protein p97 (VCP) TTHNLSB TERA_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Valosin-containing protein p97 (VCP) DTT VCP 7.586 7.773 8.676 7.705
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Acute myeloid leukaemia
ICD Disease Classification 2A60
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Valosin-containing protein p97 (VCP) DTT VCP 2.13E-05 0.88 3.55
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT04402541) Study of CB-5339 in Acute Myeloid Leukemia or Myelodysplastic Syndrome. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of Cleave Therapeutics.