Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMP3MOC)

Drug Name

Philanthotoxin-343 Drug Info

Synonyms

Philanthotoxin 343; Philanthotoxin-343; Phtx 343; AC1Q5PFY; CHEMBL16117; 115976-93-7; CHEBI:34920; AC1L4M0L; SCHEMBL8391460; N-[1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-butyramide; BDBM50094298; n-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]-n; A-butanoyl-l-tyrosinamide; C13806; Benzenepropanamide, N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-4-hydroxy-alpha-((1-oxobutyl)amino)-, (S)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 159548
ChEBI ID: CHEBI:34920
CAS Number: CAS 115976-93-7
TTD Drug ID: DMP3MOC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA 1 (GRIA1)	TTVPQTF	GRIA1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glutamate receptor AMPA 1 (GRIA1)	DTT	GRIA1	3.209	3.365	3.194	3.379

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate receptor AMPA 1 (GRIA1)	DTT	GRIA1	1.46E-06	-0.63	-0.78

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem. 2010 Feb 15;18(4):1381-7.