Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMP8NSU)

Drug Name

ADRENOGLOMERULOTROPIN Drug Info

Synonyms

Adrenoglomerulotropin; MMTC; 1210-56-6; BRN 0747865; 1-Methyl-6-methoxy-1,2,3,4-tetrahydro-beta-carboline; CHEMBL221811; RDUORFDQRFHYBF-UHFFFAOYSA-N; 6-Methoxy-1-methyl-1,2,3,4-tetrahydro-beta-carboline; 9H-Pyrido(3,4-b)indole, 1,2,3,4-tetrahydro-6-methoxy-1-methyl-; 6-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole; 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-6-methoxy-1-methyl-; 1-Methyl-6-methoxy-1,2,3,4-tetrahydro-2-carboline; 1H-Pyrido(3,4-b)indole, 2,3,4,9-tetrahydro-6-methoxy-1-methyl-; Mmthc

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 71028
CAS Number: CAS 1210-56-6
TTD Drug ID: DMP8NSU

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2B receptor (HTR2B)	TT0K1SC	5HT2B_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2B receptor (HTR2B)	DTT	HTR2B	0.485	3.536	0.379	4.667

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2B receptor (HTR2B)	DTT	HTR2B	2.08E-01	-0.05	-0.23

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify no... J Med Chem. 2010 Nov 11;53(21):7573-86.