Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMP9ECK)

Drug Name

2,2,4-Trimethyl-6-phenyl-1,2-dihydro-quinoline Drug Info

Synonyms

Santoflex B; UNII-UT9B2V4JD4; USAF B-29; 2,2,4-Trimethyl-6-phenyl-1,2-dihydroquinoline; 3562-69-4; BRN 0185528; UT9B2V4JD4; CHEMBL93463; 6-Phenyl-2,2,4-trimethyldihydroquinoline; 1,2-Dihydro-2,2,4-trimethyl-6-phenylquinoline; Quinoline, 1,2-dihydro-2,2,4-trimethyl-6-phenyl-; 2,2,4-trimethyl-6-phenyl-1H-quinoline; AC1L2SCX; 2,2,4-Trimethyl-6-phenyl-1,2-dihydro-quinoline; 4-20-00-04116 (Beilstein Handbook Reference); SCHEMBL311413; DTXSID30189094; ZINC5315096; BDBM50066527; ACM3562694; LS-141859

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 77098
CAS Number: CAS 3562-69-4
TTD Drug ID: DMP9ECK

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Progesterone receptor (PGR)	TTUV8G9	PRGR_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Progesterone receptor (PGR)	DTT	PGR	1.848	1.888	1.263	0.138

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Progesterone receptor (PGR)	DTT	PGR	3.26E-38	-3.79	-2.5

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore. J Med Chem. 1998 Aug 27;41(18):3461-6.