Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMPBKUZ)

• Drug Name: SCH-900978 Drug Info
• Synonyms: Neurokinin 1 receptor antagonist (emesis), OPKO Health

Indication

Disease Entry	ICD 11	Status	REF
Cough	MD12	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 11671080
  CAS Number: CAS 873947-10-5
  TTD Drug ID: DMPBKUZ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Substance-P receptor (TACR1)	TTZPO1L	NK1R_HUMAN	Antagonist	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Substance-P receptor (TACR1)	DTT	TACR1	3.597	4.186	4.271	5.113

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Cough
• ICD Disease Classification: MD12

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Substance-P receptor (TACR1)	DTT	TACR1	7.40E-01	0.02	0.07
Substance-P receptor (TACR1)	DTT	TACR1	8.57E-01	-0.02	-0.18

References

• [1] Clinical pipeline report, company report or official report of OPKO Health Inc.
• [2] Clinical pipeline report, company report or official report of OPKO Health, Inc.