Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMPJRHX)

Drug Name
ATF-HI-8 Drug Info
Synonyms urokinase/urinary trypsin inhibitor chimera, Nissin/Hamamatsu University
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
TTD Drug ID
DMPJRHX

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cationic trypsinogen (PRSS1) TT2WR1T TRY1_HUMAN Modulator [1]
Urokinase-type plasminogen activator (PLAU) TTGY7WI UROK_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Urokinase-type plasminogen activator (PLAU) DTT PLAU 5.352 5.741 6.924 6.898
Cationic trypsinogen (PRSS1) DTT PRSS1 3.217 4.018 1.585 3.121
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Urokinase-type plasminogen activator (PLAU) DTT PLAU 5.32E-70 1.07 1.82
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Inhibitory effect of a conjugate between human urokinase and urinary trypsin inhibitor on tumor cell invasion in vitro. J Biol Chem. 1995 Apr 7;270(14):8361-6.