Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMPLV3A)

• Drug Name: 2-(2-(2-chlorophenylamino)phenyl)acetic acid Drug Info
• Synonyms: CHEMBL77823; 488862-17-5; 2-(2-(2-chlorophenylamino)phenyl)acetic acid; SCHEMBL6243911; CTK1D1110; DTXSID00548437; RXRLPBIKRNGLJD-UHFFFAOYSA-N; ZINC26400000; BDBM50295275; AKOS030583290; [2-(2-Chloroanilino)phenyl]acetic acid; 2-(2-Chlorophenylamino)benzeneacetic acid; 2-[(2-chlorophenyl)amino]phenylacetic acid; Benzeneacetic acid, 2-[(chlorophenyl)amino]-; [2-(2-Chloro-phenylamino)-phenyl]-acetic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 13752584
  CAS Number: CAS 488862-17-5
  TTD Drug ID: DMPLV3A

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-8 (IL8)	TTCTE1G	IL8_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Interleukin-8 (IL8)	DTT	CXCL8	4.892	4.17	4.65	3.807

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Interleukin-8 (IL8)	DTT	CXCL8	9.05E-17	2.09	3.08

References

• [1] Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30.