Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMPUARE)

• Drug Name: 2-(Phenylamino)-6-(3-acetamidophenyl)pyrazine Drug Info
• Synonyms: CHEMBL425576; 2-(Phenylamino)-6-(3-acetamidophenyl)pyrazine; SCHEMBL1122285

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 11515006
  TTD Drug ID: DMPUARE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
B-Raf messenger RNA (BRAF mRNA)	TT0EOB8	BRAF_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
B-Raf messenger RNA (BRAF mRNA)	DTT	BRAF	6.409	7.097	6.062	6.049

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
B-Raf messenger RNA (BRAF mRNA)	DTT	BRAF	1.56E-01	-0.23	-0.43

References

• [1] Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead. J Med Chem. 2006 Jan 12;49(1):407-16.