General Information of Drug (ID: DMPW75L)

Drug Name
1-methyl-1H-indole-2,3-dione Drug Info
Synonyms
N-Methylisatin; 2058-74-4; 1-Methylisatin; 1-methylindoline-2,3-dione; 1-Methyl-1H-indole-2,3-dione; 1-methylindole-2,3-dione; 1H-Indole-2,3-dione, 1-methyl-; 1-Methyl-indole-2,3-dione; NSC 42449; 1 methylisatine; OL-57; 1-methyl-2,3-dihydro-1H-indole-2,3-dione; 1-Methyl-2,3-indolinedione; INDOLE-2,3-DIONE, 1-METHYL-; EINECS 218-164-9; N-methylindol-2,3-dione; BRN 0128280; N-Methylindoline-2,3-dione; 1-Methyl-2,3-dihydroindole-2,3-dione; CHEMBL60569; VCYBVWFTGAZHGH-UHFFFAOYSA-N; MFCD00005812; 1-Methylisatin, 98%
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
16358
CAS Number
CAS 2058-74-4
TTD Drug ID
DMPW75L

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Liver carboxylesterase (CES1) TTMF541 EST1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Liver carboxylesterase (CES1) DTT CES1 12.04 6.525 5.311 5.909
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Liver carboxylesterase (CES1) DTT CES1 3.82E-08 1.86 1.9
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85.