Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQ46DN)

Drug Name
GW-796406 Drug Info
Synonyms N-[3-Methyl-2(S)-(sulfanylmethyl)butyryl]-4-(1H-pyrazol-1-yl)-L-phenylalanine; 796406
Indication
Disease Entry ICD 11 Status REF
Hypotension BA20-BA21 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMQ46DN

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin-converting enzyme (ACE) TTL69WB ACE_HUMAN Modulator [2]
Neutral endopeptidase (MME) TT5TKPM NEP_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Angiotensin-converting enzyme (ACE) DTT SLC33A1 2.561 2.511 2.379 7.031
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Hypotension
ICD Disease Classification BA20-BA21
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Angiotensin-converting enzyme (ACE) DTT SLC33A1 2.62E-01 -0.01 -0.06
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-... J Pharmacol Exp Ther. 2005 Dec;315(3):1306-13.
2 Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406. J Pharmacol Exp Ther. 2005 Dec;315(3):1306-13.