Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQ7UN6)

Drug Name
Trodusquemine Drug Info
Synonyms Produlestan; Trodulamine; Aminosterol 1436; MSI-1436; Aminosterols (obesity, type 2 diabetes), Genaera
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 1 [1]
Obesity 5B81 Phase 1 [2]
Cross-matching ID
PubChem CID
9917968
CAS Number
CAS 186139-09-3
TTD Drug ID
DMQ7UN6

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Protein-tyrosine phosphatase 1B (PTP1B) TTMS7KP PTN1_HUMAN Inhibitor [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Protein-tyrosine phosphatase 1B (PTP1B) DTT PTPN1 3.667 2.293 2.609 4.573
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Breast cancer
ICD Disease Classification 2C60-2C65
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Protein-tyrosine phosphatase 1B (PTP1B) DTT PTPN1 9.44E-01 7.21E-03 0.08
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT00806338) An Ascending Multi-Dose, Tolerance and Pharmacokinetic Study in Obese or Overweight Type 2 Diabetic Volunteers. U.S. National Institutes of Health.
3 Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug;18(8):1516-23.