Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQA1VT)

Drug Name
Autologous cell based gene therapy Drug Info
Synonyms Autologous cell based gene therapy (pulmonary hypertension)
Indication
Disease Entry ICD 11 Status REF
Pulmonary hypertension BB01 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMQA1VT

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nitric-oxide synthase endothelial (NOS3) TTCM4B3 NOS3_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Nitric-oxide synthase endothelial (NOS3) DTT NOS3 4.787 4.154 5.133 3.053
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Pulmonary hypertension
ICD Disease Classification BB01
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Nitric-oxide synthase endothelial (NOS3) DTT NOS3 3.68E-01 -0.11 -0.85
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 A Phase I study of the transplantation of genetically marked autologous bone marrow stromal cells. Hum Gene Ther. 1998 Mar 1;9(4):591-600.
2 Feasibility of using autologous transplantation to evaluate hematopoietic stem cell-based gene therapy strategies in transgenic mouse models of human disease. Mol Ther. 2002 Sep;6(3):422-8.