Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQH2DK)

Drug Name
CAR-GPC3 T Cells Drug Info
Indication
Disease Entry ICD 11 Status REF
Lung squamous cell carcinoma 2C25.2 Phase 1 [1]
Hepatocellular carcinoma 2C12.02 Clinical trial [2]
Cross-matching ID
TTD Drug ID
DMQH2DK

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glypican-3 (GPC3) TTJTSX4 GPC3_HUMAN CAR-T-Cell-Therapy [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Glypican-3 (GPC3) DTT GPC3 5.641 5.661 6.547 5.174
Glypican-3 (GPC3) DTT GPC3 5.641 5.661 6.547 5.174
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Lung squamous cell carcinoma
ICD Disease Classification 2C25.2
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glypican-3 (GPC3) DTT GPC3 5.54E-86 3 9.74
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT02876978) Anti-GPC3 CAR T for Recurrent or Refractory Lung Squamous Cell Carcinoma
2 ClinicalTrials.gov (NCT03146234) CAR-GPC3 T Cells in Patients With Refractory Hepatocellular Carcinoma