Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQHTR4)

Drug Name

1-(4-chlorophenyl)-2-(phenylsulfonyl)ethanone Drug Info

Synonyms

1-(4-Chlorophenyl)-2-(phenylsulfonyl)ethanone; 38488-19-6; CHEMBL238834; 1-(4-chlorophenyl)-2-(phenylsulfonyl)-1-ethanone; 4-Chlorophenacylphenyl sulfone; AC1LBPW5; SCHEMBL10931021; ZINC58239; CTK6G9147; MolPort-002-876-864; KZACHGLUJYSTGQ-UHFFFAOYSA-N; BDBM50212531; CCG-43075; AKOS003310153; MCULE-9299558448; 7H-330S; KS-00001Z91; ST50308734; Ethanone, 1-(4-chlorophenyl)-2-phenylsulfonyl-; 4'-CHLORO-2(PHENYL SULFONYL)ACETOPHENONE; 2-(benzenesulfonyl)-1-(4-chlorophenyl)ethanone; AF-731/00081054

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 586971
TTD Drug ID: DMQHTR4

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	TTN7BL9	DHI1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	10.967	5.178	5.865	6.377

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	2.03E-01	-0.01	-0.08

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405.