Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQNX02)

• Drug Name: GYKI-12743 Drug Info
• Synonyms: GYKI-12743; Gyki 12743; GKYI-12743; 110714-10-8; 2-(3-(Benzo(1,4)dioxan-2-ylmethylamino)-1-propyl)-3(2H)-pyridazinone hydrochloride; 2-{3-[(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amino]propyl}pyridazin-3(2h)-one hydrochloride(1:1); 133983-22-9; 3(2H)-Pyridazinone, 2-[3-[[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amino]propyl]-, hydrochloride (1:1); 3(2H)-Pyridazinone, 2-(3-(((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)amino)propyl)-, monohydrochloride; AC1Q3EJF; AC1L4TO4; SCHEMBL7284667; CTK4B8909; LS-129872

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Discontinued in Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 163825
  CAS Number: CAS 110714-10-8
  TTD Drug ID: DMQNX02

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Modulator	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	5.013	2.379	5.594	2.07

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Hypertension
• ICD Disease Classification: BA00-BA04

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002059)
• [2] GYKI-12743 a new postsynaptic vascular alpha-adrenoceptor antagonist. Acta Physiol Hung. 1991;77(3-4):257-67.