Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMR0K85)

Drug Name

RX-77368 Drug Info

Synonyms

TRH analog, Reckitt & Colman

Indication

Disease Entry	ICD 11	Status	REF
Dementia	6D80-6D86	Discontinued in Phase 2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thyrotropin-releasing hormone (TRH)	TT2Z39D	TRH_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Thyrotropin-releasing hormone (TRH)	DTT	TRH	4.07	1.263	3.485	4

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Dementia

ICD Disease Classification

6D80-6D86

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Thyrotropin-releasing hormone (TRH)	DTT	TRH	2.52E-01	0.09	0.49

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001316)
2	Intracisternal urocortin inhibits vagally stimulated gastric motility in rats: role of CRF(2).Br J Pharmacol.2002 May;136(2):237-47.