Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMR1NYF)

Drug Name
KH064 Drug Info
Synonyms sPLA2-2A inhibitor, compound 2b
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Clinical trial [1]
Cross-matching ID
PubChem CID
446400
CAS Number
CAS 393569-31-8
TTD Drug ID
DMR1NYF

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Group IIA phospholipase A2 (GIIA sPLA2) TTO8QRU PA2GA_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Group IIA phospholipase A2 (GIIA sPLA2) DTT PLA2G2A 9.464 8.495 5.655 10.995
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Breast tissue
The Studied Disease Breast cancer [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Group IIA phospholipase A2 (GIIA sPLA2) DTT PLA2G2A 6.13E-08 -0.54 -0.33
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity. Chembiochem. 2003 Mar 3;4(2-3):181-5.