Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMR37X8)

Drug Name
TTP-448 Drug Info
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMR37X8

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Advanced glycosylation end product receptor (AGER) TTMO9HF RAGE_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Advanced glycosylation end product receptor (AGER) DTT AGER 4.347 2.379 1.945 4.233
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Alzheimer disease
ICD Disease Classification 8A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Advanced glycosylation end product receptor (AGER) DTT AGER 7.92E-01 6.77E-03 0.04
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Biopharmaceutical Research Companies are Developing Nearly 100 Medicines for Alzheimer's Disease and Other Dementias. Pharmaceutical Research and Manufacturers of America report. 2012.
2 Receptor for advanced glycation endproduct modulators: a new therapeutic target in Alzheimer's disease. Expert Opin Investig Drugs. 2015 Mar;24(3):393-9.