Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMR9OD1)

Drug Name
Angiotensin IV Drug Info
Synonyms
Nle-angiv; Human angiotensin IV; Ile3-angiotensin IV; Huamn angiotensin (3-8); Ang IV; VAL-TYR-ILE-HIS-PRO-PHE; Angiotensin II (3-8), human; 1-De-asp-2-de-arg-5-ile-angiotensin II; (Ile5)-angiotensin II (3-8); Human angiotensin hexapeptide (3-8); (3-8)-5-Isoleucine-angiotensin II; (Des(Asp1,Arg2)-Ile5)angiotensin II; (Isoleucine5)-angiotensin II hexapeptide; CHEMBL261120; 12676-15-2; 5-Isoleucine-angiotensin II 3-8-hexapeptide; 23025-68-5; ANGIOTENSIN I/II (3-8); Angiotensin II (3-8); MLS000069773
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
123814
ChEBI ID
CHEBI:80127
CAS Number
CAS 23025-68-5
TTD Drug ID
DMR9OD1

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aminopeptidase N (ANPEP) TTPHMWB AMPN_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Aminopeptidase N (ANPEP) DTT ANPEP 8.744 7.809 8.914 11.49
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Aminopeptidase N (ANPEP) DTT ANPEP 8.84E-07 -0.3 -0.71
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5368).
2 Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2. Bioorg Med Chem. 2008 Jul 15;16(14):6924-35.