Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMRCH1M)

Drug Name
MOR-102 Drug Info
Synonyms MOR-101; MOR-101); ICAM-1 antibody (inflammation), MorphoSys
Indication
Disease Entry ICD 11 Status REF
Psoriasis vulgaris EA90 Terminated [1]
Cross-matching ID
TTD Drug ID
DMRCH1M

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Intercellular adhesion molecule ICAM-1 (ICAM1) TTCT6F7 ICAM1_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Intercellular adhesion molecule ICAM-1 (ICAM1) DTT ICAM1 7.993 5.81 6.662 5.926
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Psoriasis vulgaris
ICD Disease Classification EA90
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Intercellular adhesion molecule ICAM-1 (ICAM1) DTT ICAM1 5.21E-01 0.38 0.32
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017213)
2 Efficacy of the fully human monoclonal antibody MOR102 (#5) against intercellular adhesion molecule 1 in the psoriasis-severe combined immunodeficient mouse model. Br J Dermatol. 2005 Oct;153(4):758-66.