Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMRDEKZ)

Drug Name

LY2928057 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Anaemia	3A90	Phase 2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Solute carrier family 40 member 1 (SLC40A1)	TT6Y1PG	S40A1_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Anaemia

ICD Disease Classification

3A90

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Solute carrier family 40 member 1 (SLC40A1)	DTT	SLC40A1	6.38E-02	0.15	0.5

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. 2017 Jun;16(6):400-423.
2	Targeting the Hepcidin-Ferroportin Axis to Develop New Treatment Strategies for Anemia of Chronic Disease and Anemia of Inflammation. Am J Hematol. 2012 April; 87(4): 392-400.