Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMREQCF)

Drug Name
CAR-T Cells targeting EpCAM Drug Info
Indication
Disease Entry ICD 11 Status REF
Colon cancer 2B90.Z Phase 1/2 [1]
Esophageal cancer 2B70 Phase 1/2 [1]
Gastric adenocarcinoma 2B72 Phase 1/2 [1]
Hepatocellular carcinoma 2C12.02 Phase 1/2 [1]
Pancreatic cancer 2C10 Phase 1/2 [1]
Prostate cancer 2C82.0 Phase 1/2 [1]
Metastatic cancer 2D50-2E2Z Phase 1 [2]
Cross-matching ID
TTD Drug ID
DMREQCF

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tumor-associated calcium signal transducer 1 (EPCAM) TTZ8WH4 EPCAM_HUMAN CAR-T-Cell-Therapy [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Tumor-associated calcium signal transducer 1 (EPCAM) DTT EPCAM 4.307 10.904 9.628 10.804
Tumor-associated calcium signal transducer 1 (EPCAM) DTT EPCAM 4.307 10.904 9.628 10.804
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Colon cancer
ICD Disease Classification 2B90.Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tumor-associated calcium signal transducer 1 (EPCAM) DTT EPCAM 5.99E-02 -0.11 -1.11
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT03013712) A Clinical Research of CAR T Cells Targeting EpCAM Positive Cancer
2 ClinicalTrials.gov (NCT03563326) Intraperitoneal Infusion of EpCAM CAR-T Cell in Advanced Gastric Cancer With Peritoneal Metastasis (WCH-GC-CART)