Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMS2GA1)

• Drug Name: Bindarit Drug Info
• Synonyms: Bindarit, Angelini Pharmaceuticals; CCL2 inhibitor (inflammatory disorders/kidney disease), Angelini Pharmaceuticals; MCP-1 inhibitor (inflammatory disorder/kidney disease), Angelini Pharmaceuticals

Indication

Disease Entry	ICD 11	Status	REF
Nephritis	GB40	Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 71354
  CAS Number: CAS 130641-38-2
  TTD Drug ID: DMS2GA1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monocyte chemotactic and activating factor (CCL2)	TTNAY0P	CCL2_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monocyte chemotactic and activating factor (CCL2)	DTT	CCL2	6.553	4.907	7.825	6.946

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Nephritis
• ICD Disease Classification: GB40

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monocyte chemotactic and activating factor (CCL2)	DTT	CCL2	3.76E-06	3.57	4.42

References

• [1] Bindarit: an anti-inflammatory small molecule that modulates the NF B pathway. Cell Cycle. 2012 Jan 1;11(1):159-69.