Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMS4ZFU)

Drug Name

Pyrrolidin-(2Z)-ylideneamine Drug Info

Synonyms

3,4-dihydro-2H-pyrrol-5-amine; 872-34-4; Pyrrolidin-2-imine; Pyrrolidin-(2Z)-ylideneamine; 4,5-DIHYDRO-3H-PYRROL-2-YLAMINE; CHEMBL161318; 2-Amino-1-pyrroline; iminopyrrolidine; 2-iminopyrrolidine; 2-imino pyrrolidine; 2-imino-pyrrolidine; 2-Amino-1-pyrrolin; PYR040; CTK5F8124; DTXSID60509645; NJBMZYSKLWQXLJ-UHFFFAOYSA-N; MolPort-004-968-713; 2-amino-4,5-dihydro-3H-pyrrole; 2H-Pyrrol-5-amine,3,4-dihydro-; BDBM50049251; BBL031757; ZINC12946088; STL283815; ANW-72957; 3788AC; 2H-Pyrrol-5-amine, 3,4-dihydro-; AKOS009098397; AKOS002684118

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 12778904
CAS Number: CAS 872-34-4
TTD Drug ID: DMS4ZFU

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase brain (NOS1)	TTZUFI5	NOS1_HUMAN	Inhibitor	[1]
Nitric-oxide synthase endothelial (NOS3)	TTCM4B3	NOS3_HUMAN	Inhibitor	[1]
Nitric-oxide synthase inducible (NOS2)	TTF10I9	NOS2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	6.085	5.844	5.849	5.806
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.95	5.198	4.573	5.121
Nitric-oxide synthase endothelial (NOS3)	DTT	NOS3	4.787	4.154	5.133	3.053

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.24E-02	-0.27	-0.88

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44.