Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMS72GN)

Drug Name
AMG 172 Drug Info
Indication
Disease Entry ICD 11 Status REF
Renal cell carcinoma 2C90 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMS72GN

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CD70 antigen (CD27-L) TTNCIE0 CD70_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
CD70 antigen (CD27-L) DTT CD70 5.138 3.35 4.621 2.907
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Renal cell carcinoma
ICD Disease Classification 2C90
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
CD70 antigen (CD27-L) DTT CD70 1.53E-09 0.76 2.84
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01497821) AMG 172 First in Human Study in Patients With Kidney Cancer. U.S. National Institutes of Health.
2 National Cancer Institute Drug Dictionary (drug id 721679).