Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSC7TN)

Drug Name
Rimacalib Drug Info
Synonyms SMP-114
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Phase 2 [1]
Cross-matching ID
PubChem CID
9800765
CAS Number
CAS 215174-50-8
TTD Drug ID
DMSC7TN

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CaM-kinase II (CAMK2) TTFYL58 KCC2A_HUMAN; KCC2B_HUMAN; KCC2D_HUMAN; KCC2G_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
CaM-kinase II (CAMK2) DTT CAMK2A 5.567 3.162 4.85 3.945
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 15 Disease of the musculoskeletal system/connective tissue
Disease Class ICD-11: FA20 Rheumatoid arthritis
The Studied Tissue Synovial tissue
The Studied Disease Rheumatoid arthritis [ICD-11:FA20]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
CaM-kinase II (CAMK2) DTT CAMK2A; CAMK2B; CAMK2D; CAMK2G 1.34E-02 -0.33 -0.93
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 CaMKII inhibitors: from research tools to therapeutic agents. Front Pharmacol. 2014; 5: 21.
2 Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts. Ann N Y Acad Sci. 2009 Sep;1173:706-11.