Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSE9TH)

Drug Name
MT-1303 Drug Info
Indication
Disease Entry ICD 11 Status REF
Crohn disease DD70 Phase 2 [1]
Multiple sclerosis 8A40 Phase 2 [2]
Cross-matching ID
PubChem CID
67418070
CAS Number
CAS 942398-84-7
TTD Drug ID
DMSE9TH

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sphingosine-1-phosphate receptor 1 (S1PR1) TT9JZCK S1PR1_HUMAN Modulator [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Sphingosine-1-phosphate receptor 1 (S1PR1) DTT S1PR1 6.829 6.89 6.853 5.959
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Crohn disease
ICD Disease Classification DD70
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Sphingosine-1-phosphate receptor 1 (S1PR1) DTT S1PR1 1.41E-119 -2.24 -3.66
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT01890655) Extension Study of MT-1303. U.S. National Institutes of Health.
3 Sphingosine 1-Phosphate Receptor Modulators in Multiple Sclerosis. CNS Drugs. 2015 Jul;29(7):565-75.