General Information of Drug (ID: DMSF4UI)

Drug Name
MDT-006 Drug Info
Synonyms
EPX-16006; Chronic constipation, IBS-C therapy (PolyCap), MicroDose Therapeutx; P2Y2 agonist (oral, constipation/irritable bowel syndrome), EPIX; Purinoceptor P2Y2 agonist (oral, constipation/IBS), EPIX
Indication
Disease Entry ICD 11 Status REF
Constipation DD91.1 Investigative [1]
Cross-matching ID
TTD Drug ID
DMSF4UI

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
P2Y purinoceptor 2 (P2RY2) TTOZHQC P2RY2_HUMAN Agonist [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
P2Y purinoceptor 2 (P2RY2) DTT P2RY2 2.406 1.848 4.154 1.888
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Constipation
ICD Disease Classification DD91.1
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
P2Y purinoceptor 2 (P2RY2) DTT P2RY2 7.03E-10 0.14 0.52
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 324).