Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSHPCW)

Drug Name

2-(4-Amino-3'-chloro-biphenyl-3-yl)-propan-2-ol Drug Info

Synonyms

CHEMBL350283; SCHEMBL6770087; ITEDDYPYHIHWHC-UHFFFAOYSA-N; BDBM50110507; 2-[2-Amino-5-(3-chlorophenyl)phenyl]-2-propanol; (4-amino-3'-chloro-biphenyl-3-yl)-dimethyl-methanol; 2-(4-Amino-3''-chloro-biphenyl-3-yl)-propan-2-ol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 15908132
TTD Drug ID: DMSHPCW

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Progesterone receptor (PGR)	TTUV8G9	PRGR_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Progesterone receptor (PGR)	DTT	PGR	1.848	1.888	1.263	0.138

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Progesterone receptor (PGR)	DTT	PGR	3.26E-38	-3.79	-2.5

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Potent nonsteroidal progesterone receptor agonists: synthesis and SAR study of 6-aryl benzoxazines. Bioorg Med Chem Lett. 2002 Mar 11;12(5):787-90.