Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSLT3I)

Drug Name

6-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Drug Info

Synonyms

2-amino-5,6-dihydro-6-methyl-4h-1,3-thiazine; 1121-91-1; 6-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine; (+/-)-AMT hydrochloride; 4H-1,3-Thiazin-2-amine, 5,6-dihydro-6-methyl-; AC1L1BOF; Lopac0_000085; SCHEMBL523755; CHEMBL106322; CHEBI:91610; MolPort-009-018-788; BATVOUKHGLKDGQ-UHFFFAOYSA-N; FCH842002; AKOS006274541; CCG-204180; NCGC00024834-02; NCGC00015114-03; NCGC00015114-04; KB-19997; 5,6-dihydro-6-methyl-4h-1,3-thiazin-2-amine; C-41564

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1534
ChEBI ID: CHEBI:91610
TTD Drug ID: DMSLT3I

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase inducible (NOS2)	TTF10I9	NOS2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.95	5.198	4.573	5.121

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.24E-02	-0.27	-0.88

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis of biflavones having a 6-O-7'' linkage and effects on cyclooxygenase-2 and inducible nitric oxide synthase. Bioorg Med Chem Lett. 2009 Jan 1;19(1):74-6.