Details of the Drug-Related molecule(s) Expression Atlas

8-amino-9-benzylguanine Drug Info

8-Amino-9-benzylguanine; 100890-94-6; NSC650999; CHEMBL8230; NSC-650999; 6H-Purin-6-one,2,8-diamino-1,9-dihydro-9-(phenylmethyl)-; 8-Amino-9-benzyl-guanine; 8-ABG; 2,8-diamino-9-benzyl-3H-purin-6-one; ACMC-20m3xx; AC1L2SFN; SCHEMBL6359274; CTK3J9334; ZINC16958226; BDBM50005799; AKOS030559033; NCI60_017833; 2-amino-9-benzyl-8-imino-7H-purin-6-ol; 2-Amino-9-benzyl-8-imino-8,9-dihydro-7H-purin-6-ol; 6H-Purin-6-one,

Cross-matching ID

PubChem CID

135408972

CAS Number

CAS 100890-94-6

TTD Drug ID

DMSNG7M

General Information of Drug (ID: DMSNG7M)

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Purine nucleoside phosphorylase (PNP)	TTMCF1Y	PNPH_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Purine nucleoside phosphorylase (PNP)	DTT	PNP	7.85	7.15	8.34	8.782

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Purine nucleoside phosphorylase (PNP)	DTT	PNP	3.67E-04	1.95	2.55

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors. J Biol Chem. 1986 Sep 5;261(25):11667-73.