Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSPH30)

Drug Name

PRX-111 Drug Info

Synonyms

FSH variants (female infertility), Protalix Biotherapeutics/ Compugen; Follicle stimulating hormone variants (female infertility), Protalix Biotherapeutics/ Compugen

Indication

Disease Entry	ICD 11	Status	REF
Female infertility	GA31.Z	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMSPH30

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Follicle-stimulating hormone receptor (FSHR)	TTZFDBT	FSHR_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Follicle-stimulating hormone receptor (FSHR)	DTT	FSHR	3.233	3.945	3.392	4.426

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Female infertility

ICD Disease Classification

GA31.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Follicle-stimulating hormone receptor (FSHR)	DTT	FSHR	1.56E-02	-0.56	-1.34

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028182)
2	A naturally occurring basically charged human follicle-stimulating hormone (FSH) variant inhibits FSH-induced androgen aromatization and tissue-type plasminogen activator enzyme activity in vitro. Neuroendocrinology. 1998 Mar;67(3):153-63.