Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSROM4)

Drug Name
BHQ880 Drug Info
Synonyms BHQ-880A; Anti-DKK1 monoclonal antibody (multiple myeloma), Novartis
Indication
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMSROM4

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dickkopf-related protein 1 (DKK1) TTE3RAC DKK1_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dickkopf-related protein 1 (DKK1) DTT DKK1 5.591 4.916 5.174 4.848
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Bone marrow
The Studied Disease Multiple myeloma [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dickkopf-related protein 1 (DKK1) DTT DKK1 5.31E-07 2.97 5.21
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01302886) Study of BHQ880 in Patients With High Risk Smoldering Multiple Myeloma. U.S. National Institutes of Health.
2 Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood. 2009 Jul 9;114(2):371-9.