Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMST5VW)

• Drug Name: amidephrine Drug Info
• Synonyms: amidephrine; Amidefrine; Amidefrine mesilate; UNII-U56LDN9FFT; 37571-84-9; UNII-NI24N176MY; U56LDN9FFT; NI24N176MY; 3354-67-4; Amidephrine, (+)-; N-(3-(1-Hydroxy-2-(methylamino)-ethyl)phenyl)methanesulfonamide; Amidephrine, (-)-; Amidefrine [INN:BAN]; Amidefrin; AC1L24YQ; GTPL514; SCHEMBL122479; CHEMBL146408; ZHOWHMXTJFZXRB-UHFFFAOYSA-N; CHEBI:134994; N-[3-[1-hydroxy-2-(methylamino)ethyl]phenyl]methanesulfonamide; BDBM50225291; Methanesulfonamide, N-(3-(1-hydroxy-2-(methylamino)ethyl)phenyl)-, (-)-; Methanesulfonamide, N-(3-(1-hy

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 15010
  ChEBI ID: CHEBI:134994
  CAS Number: CAS 37571-84-9
  TTD Drug ID: DMST5VW

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Agonist	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	5.013	2.379	5.594	2.07

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 514).
• [2] Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36.