Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSW07R)

Drug Name

GLPG-0492 Drug Info

Synonyms

G-100192; Selective androgen receptor modulators, Galapagos; Selective androgen receptor modulators, ProSkelia; Selective androgen receptor modulators, ProStrakan; SARMs (osteoporosis), ProSkelia; SARMs (osteoporosis), ProStraken; SARMs (osteoporosis/cachexia), Galapagos

Indication

Disease Entry	ICD 11	Status	REF
Cachexia	MG20	Preclinical	[1]

Cross-matching ID

PubChem CID: 59317190
CAS Number: CAS 1215085-92-9
TTD Drug ID: DMSW07R

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Androgen receptor (AR)	TTS64P2	ANDR_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Androgen receptor (AR)	DTT	AR	5.955	4.868	5.902	5.567

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Cachexia

ICD Disease Classification

MG20

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Androgen receptor (AR)	DTT	AR	2.13E-01	-0.07	-0.11

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018432)
2	GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy. Pharmacol Res. 2013 Jun;72:9-24.