Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSXOPE)

Drug Name
JNJ-26070109 Drug Info
Synonyms CCK2 receptor antagonists, (oral, cancer); CCK2 receptor antagonists, (oral, cancer),Johnson & Johnson Pharmaceutical Research & Development
Indication
Disease Entry ICD 11 Status REF
Gastroesophageal reflux disease DA22.Z Preclinical [1]
Cross-matching ID
PubChem CID
11307323
TTD Drug ID
DMSXOPE

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Gastrin/cholecystokinin type B receptor (CCKBR) TTVFO0U GASR_HUMAN Antagonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Gastrin/cholecystokinin type B receptor (CCKBR) DTT CCKBR 5.618 5.638 5.466 6.002
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Gastroesophageal reflux disease
ICD Disease Classification DA22.Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Gastrin/cholecystokinin type B receptor (CCKBR) DTT CCKBR 6.53E-01 1.00E-03 4.05E-03
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6665).
2 The cholecystokinin CCK2 receptor antagonist, JNJ-26070109, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat. Br J Pharmacol. 2012 Jul;166(5):1684-93.