Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSYT0A)

Drug Name

NSC-87509 Drug Info

Synonyms

Salazinic acid; SALAZIC ACID; 521-39-1; NSC-87509; NSC87509; CHEMBL172439; Salacinic acid; EINECS 208-312-0; Salazinic acid, 2; NSC 87509; C18H12O10; MLS001049106; SCHEMBL3801772; cid_5320418; BDBM29673; MolPort-002-514-253; AKOS030493208; MCULE-8620897210; NCGC00241204-01; NCI60_041934; SMR000386938; trihydroxy-(hydroxymethyl)-methyl-dioxo-[ ]carbaldehyde; 7H-Isobenzofuro[4,5-b][1,4]benzodioxepin-11-carboxaldehyde,1,3-dihydro-1,4,10-trihydroxy-5-(hydroxymethyl)-8-methyl-3,7-dioxo-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5320418
CAS Number: CAS 521-39-1
TTD Drug ID: DMSYT0A

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha Cav2.2 (CACNA1B)	TT4FDG6	CAC1B_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Voltage-gated calcium channel alpha Cav2.2 (CACNA1B)	DTT	CACNA1B	4.087	2.433	1.632	3.392

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Voltage-gated calcium channel alpha Cav2.2 (CACNA1B)	DTT	CACNA1B	9.07E-01	7.11E-03	0.06

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.